Zotsatira za magalasi ophimbidwa ndi mankhwala paumoyo wapamaso

M'zaka khumi zapitazi, kafukufuku ndi chitukuko cha mankhwala a ophthalmic kwachititsa kuti pakhale njira zatsopano zoberekera, monga ma implants operekera nthawi ndi ma nanoparticles olowera mucus, zomwe zingathe kusintha mphamvu ya mankhwala, kuchepetsa zotsatirapo, ndi kuchepetsa nkhawa zokhudzana ndi kutsata odwala ndi machitidwe a maso. .madontho.modes.
Magalasi olumikizana amawonedwa ngati njira yodalirika, ndipo magalasi opaka mankhwala akufufuzidwa pa matenda, matenda a diso louma (DES), glaucoma, ndi ziwengo.imodzi
Первая контактная линза с лекарственным покрытием, получившая одобрение FDA ранее в этом году (Acuvue Theravision с кетотифеном [Johnson & Johnson Vision]), представляет собой этафилкон А для ежедневного применения, обладающий противовоспалительными свойствами, обычно используемый в глазных каплях от аллергии. Lens yoyamba yolumikizidwa ndi mankhwala kulandira chivomerezo cha FDA koyambirira kwa chaka chino (Acuvue Theravision with Ketotifen [Johnson & Johnson Vision]), ndi etafilcon A anti-inflammatory ya tsiku ndi tsiku, yomwe imagwiritsidwa ntchito kwambiri m'madontho a diso.ketotifen.

Ma Lens Odziwika Kwambiri
Malensi olumikizana nawo amagwira ntchito ngati madontho a maso.2 Popeza iyi ndi njira yatsopano yoyikamo, panthawi ya kafukufuku wachipatala wa lens iyi, anzanga ndi ine tinasonkhanitsa deta yowonjezera kuti tikwaniritse.
Tinasanthula mayesero azachipatala a 2 ndi mapangidwe omwewo omwe amayendetsedwa mosasinthika, omwe adaphatikizapo odwala oposa 500.Zotsatira, zomwe zasindikizidwa posachedwa mu Clinical and Experimental Optometry, zimajambula chithunzi chodalirika kwa odwala, akatswiri, ndi tsogolo la njirayi.3
Kugwiritsidwa ntchito kwa nthawi yaitali kwa madontho a maso kumadziwika kuti kumayambitsa mankhwala osokoneza bongo - kufiira, kutupa ndi kutentha kwa maso pambuyo poyang'ana kwa nthawi yaitali ndi zosakaniza za madontho (makamaka zotetezera).zinayi
Kusasangalatsa kumeneku sikumangosokoneza zochitika za tsiku ndi tsiku za wodwalayo komanso moyo wabwino, komanso kumalepheretsa wodwalayo kuti apitirize kugwiritsa ntchito madontho a maso chifukwa wodwalayo sakufuna kuwonjezera madontho a maso ku diso lomwe lakwiya kale.5
Wodwala akakhala ndi vutoli, kutsekemera kwa cornea nthawi zambiri kumasonyeza kusokonezeka kwa umphumphu wa corneal epithelium, kutanthauza kuti chithandizo chiyenera kusinthidwa kuti diso lichiritse ndikupewa kuwonongeka kwina.
Kupewa kukhudzana ndi mankhwala oopsa, monga maso owonongeka ndi maso, n'kofunika kwambiri kuti muchepetse conjunctivitis yoyambitsidwa ndi mankhwala.
Kuthira pafupipafupi kumafunika chifukwa madontho a m'maso amakhala ndi bioavailability yochepa - 5-10% yokha ya mankhwalawa imapezeka pamwamba pa diso6-ndipo imatsukidwa mwamsanga ndi kuphethira ndi kutsekemera.
Ma lens ophimbidwa ndi mankhwala amapereka maubwino angapo omwe amatha kuthetsa mavuto ena okhudzana ndi madontho a maso, kuphatikiza:
Mankhwalawa amawonjezedwa ku mandala panthawi yopanga, yomwe imaphatikizansopo gawo loletsa kutsekereza kwa autoclave.Choncho, safuna zotetezera monga BAC, zomwe zimaphwanya mgwirizano pakati pa maselo a corneal epithelial.Lens iliyonse imapereka mlingo wosabala wa mankhwala.
Magalasi ophimbidwa ndi mankhwala amapereka mankhwala mkati mwa maola angapo, choncho amakhala pamwamba pa diso kwa nthawi yaitali kuposa madontho a m'maso omwe amatsuka mwamsanga.Kutulutsa kwa ma lens okhudzana ndi kufalikira kumawalola kuti apereke Mlingo wokhazikika m'malo mongoyenera kumwa pafupipafupi madontho amaso.
Mwa kuphatikiza chithandizo chamankhwala ndi kukonza masomphenya mu omasuka etafilcon A disposable contact lens, odwala sayenera kuganizira za ndandanda mankhwala.Izi ndizopindulitsa makamaka kwa odwala omwe amavutika kuti azikhala ndi nthawi.
Magalasi ophimbidwa ndi mankhwala amatha kuthetsa mavuto ena okhudzana ndi madontho a m'maso, koma funso lotsatira lomveka la akatswiri osamalira maso ndiloti, "Kodi zotsatira za kuvala magalasi a mankhwala pa diso ndi chiyani?"

Ma Lens Odziwika Kwambiri
Ine ndi anzanga tidasanthula zambiri kuchokera ku mayeso awiri ofanana achitetezo chachipatala omwe adatenga milungu 12 ndikuphatikiza onse ovala ma lens 560.Odwala 374 adavala ma lens oyesa ndipo odwala 186 adavala magalasi a placebo.
Kudetsa kwa cornea ndi fluorescein kunkachitika poyambira kenako pambuyo pa 1, 4, 8, ndi 12 milungu yovala mandala.Panalibe kusiyana kwakukulu pakudetsa pakati pa gulu la mandala okutidwa ndi mankhwala ndi gulu la placebo pamaulendo onse (95.86% ndi 95.88% giredi 0, motsatana, pamasabata 12).Madontho onse anali opepuka kapena ochepa.
Pambuyo pa masabata a 4 akuvala, magulu onsewa adakhala ndi kuchepa kwapang'onopang'ono kwa madontho a cornea kuchokera pazoyambira.Kusintha kodziwikiraku kungakhale chifukwa cha odwala omwe akusintha kuchoka ku magalasi awo anthawi zonse kupita kuzinthu zatsopano (etafilcon A, yomwe ili ndi madzi ambiri7) ndi/kapena kuvala regimen (kamodzi patsiku, komwe kumatulutsa equation kuchokera mu equation) kuyeretsa. magalasi azitsulo).Kutsatira magalasi ophunzirira kunali kofanana m'magulu onse awiri (pafupifupi 92%).
Pomaliza, mu phunziro lalikulu lachipatala, loyendetsedwa bwino, lopanda khungu kawiri, tikhoza kunena molimba mtima kuti antihistamine yotulutsa lens imakhudza kwambiri kukhulupirika kwa corneal epithelium.
Maso ovala magalasi okhala ndi mankhwalawa sayenera kuoneka mosiyana ndi maso omwe amavala magalasi opanda mankhwala, chomwe chili chofunikira kwambiri pakuphatikizana mopanda msoko muzochita zamtunduwu.
Palibe kusiyana pakupanga ma lens oyenerera kapena kuwunika masomphenya.Odwala amangofunika kudziwa zambiri za magalasi kuti athe kupeza masomphenya omwe akufuna komanso kuti athandizidwe kwambiri ndi vuto la maso.
Umboni wosonyeza kuti kuwonjezera kwa antihistamines sikumawonjezera kuwonongeka kwa corneal epithelial poyerekeza ndi ma lens ovomerezeka ovomerezeka ndi olimbikitsa pamene tikuyembekezera kugwiritsa ntchito njira zambiri zogwiritsira ntchito mankhwala osokoneza bongo.