Wopangidwa ndi gulu losiyanasiyana la akatswiri azaumoyo ndi ofufuza ochokera ku Yunivesite ya Purdue ndi Indiana University's School of Optometry, ukadaulo watsopano wanzeru wamagalasi wofewa wapangidwa kuti utolere muyeso wovuta wa intraocular kwa maola 24 ngati njira yodziwira glaucoma.(Chithunzi ndi Purdue University/Rebecca McElhaw)
WEST Lafayette, Indiana - Katswiri wazachipatala waku Yunivesite ya Purdue, Chi Hwan Lee, akufuna kupanga magalasi apadera anzeru omwe amatha kuyeza molondola kuthamanga kwa intraocular (IOP) m'maso mwa anthu, yomwe ingakhale gawo lomaliza popewera khungu lokhudzana ndi glaucoma.
Gulu lofufuza motsogozedwa ndi Lee, Leslie A. Geddes Associate Pulofesa wa Biomedical Engineering pa Weldon School of Biomedical Engineering ya Purdue University, apanga ukadaulo watsopano wamaso kuti uzitha kuyang'anira miyeso ya IOP ya odwala mosalekeza.
Malinga ndi Glaucoma Research Foundation, ukadaulo uwu ndi njira ina yopangira ophthalmologists kuti azindikire glaucoma, yomwe imatha kuba masomphenya popanda zizindikiro zochenjeza kapena kupweteka komanso kumakhudza anthu oposa 80 miliyoni padziko lonse lapansi.
Chodziwika chokha chomwe chingasinthidwe pachiwopsezo ndi kuchepa kwa kuthamanga kwa intraocular kwa munthu, komwe kumakhala kovuta kuwongolera kwa nthawi yayitali, makamaka pakugona.
Ngakhale kuyesa kutha kuchitidwa m'zipinda zapadera komanso makina owunikira kunyumba alipo, ali ndi malire.Mwachitsanzo, zoyezera muofesi zimatenga nthawi, pomwe matekinoloje apano apanyumba ndi ovuta, osokonekera, ndipo samasonkhanitsa deta yokwanira mu nthawi yoyenera kapena nthawi yayitali yokwanira kuti akatswiri agwiritse ntchito chidziwitsocho moyenera kuti akwaniritse bwino. kukonza.zothetsera.
Phunziroli, lofalitsidwa m'nyuzipepala ya Nature Communications, likuwunikira zamakono zamakono.Kafukufukuyu adayerekeza ukadaulo wa Purdue ndi mulingo wagolide wapano ndi makina ena owunikira kunyumba, ndikuwunika momwe ukadaulo wa Purdue umasonkhanitsira miyeso yofunikira ya IOP kwa maola 24, ngakhale mukugona.
Ukadaulowu udapangidwa ndi mainjiniya osiyanasiyana komanso ofufuza azaumoyo ochokera ku Purdue University's School of Engineering ndi Veterinary Medicine ndi Indiana University's School of Optometry.
“Kuwonjezeka kwakukulu kwa kupanikizika kwa m’mitsempha ya maso nthawi zambiri kumachitika anthu akagona, ndipo kupanikizika kwapakati pausiku nthawi zambiri kumakhala 10 mpaka 20 peresenti kuposa kupanikizika kwa masana.Ngakhale miyeso ku chipatala kapena kunyumba masana kusonyeza yachibadwa intraocular kuthamanga, masomphenya akhoza kuchitika pa tulo popanda kudziwa wodwala Zipangizo sayansi.
Li wakhala akugwira ntchito paukadaulo uwu kwa zaka 6 ndipo amagwira ntchito ndi sticktronics, zomwe ndi zomata zomwe zimagwiritsa ntchito ukadaulo wamagetsi kapena wanzeru.Labu yake ikupanga zida zotha kuvala zomwe zimatha kuwunika mosalekeza matenda osachiritsika kapena thanzi mosavutikira.
Dr. Pete Kollbaum, pulofesa ndi wothandizana nawo pa kafukufuku pa Indiana University School of Optometry komanso mkulu wa Borish Eye Research Center pasukuluyi, wakhala akugwira ntchito ndi Lee kuyambira 2019. Gulu laukadaulo laukadaulo la Kollbaum Clinical Optics Research Laboratory linathandizira pazachipatala cha anthu. mayesero ndikupereka ndemanga kuti apititse patsogolo mapangidwe.
Ma sphygmomanometers ena amakono ovala kapena zida zomwe zimayezera kuthamanga kwa intraocular zimakhala ndi tchipisi tating'onoting'ono tating'ono, zomwe zingayambitse kuchuluka kwa makulidwe ndi kusasunthika poyerekeza ndi magalasi odziwika bwino amalonda, omwe nthawi zambiri angayambitse kusapeza bwino kwa wodwalayo.Mtundu wa Lee ndi wosiyana.
"Kuti tikwaniritse chosowa ichi, tapanga magalasi apadera anzeru osavuta olumikizirana pogwiritsa ntchito mitundu yosiyanasiyana yamalonda yamagalasi ofewa kuti tiziwunikira mosalekeza kwa maola 24 a IOP ngakhale tikugona kunyumba," adatero Li.
"Magalasi athu ofewa anzeru amasunga mawonekedwe amkati mwa magalasi monga mphamvu ya kuwala, biocompatibility, kufewa, kuwonekera, kunyowa, kutsekemera kwa okosijeni komanso kuvala usiku.Kukhala ndi makhalidwe onsewa nthawi imodzi ndikofunikira kuphatikiza ma lens anzeru ofewa.Kusintha bwino kwa magalasi kukhala chithandizo cha glaucoma ndikofunikira, koma zowunikira zamakono zowoneka bwino za kuthamanga kwa magazi zilibe lusoli. ”
Purdue Contact Lens Tonometer imapanga zojambulira zopanda zingwe zomwe zimatumizidwa kwa wolandila atavala magalasi kuti ayeze IOP masana ndi chigoba chogona kuti ayeze IOP pogona.
Zambiri za rhythm ya maola 24 za IOP zitha kutumizidwa kutali kwa asing'anga kudzera pa seva yobisidwa.Ma tonometers amatha kupanga alamu omveka kuti azindikire kuchuluka kwa kuthamanga kwa intraocular, zomwe zimakulolani kuchitapo kanthu moyenera ndikuchepetsa kufunikira koyendera dokotala.
"Tonometer iyi ndiyabwino kwambiri kuposa mtundu wina uliwonse wa sensa yamagalasi yomwe takumana nayo komanso yabwino kuposa intraocular pressure sensor sensor yomwe ikupezeka pamsika," adatero Kollbaum."Izi ndichifukwa cha njira ya Lee yophimba kachipangizo pa mandala, kusunga kachipangizo kakang'ono kwambiri komanso mandala omwewo, omwe ndi ma lens omwe amayesedwa nthawi yayitali, omwe amagulitsidwa, pogwiritsa ntchito maphunziro azachipatala ndi nthawi yofananira ndi opanga ma lens kuti awonetsetse. mandala otani Chitonthozo ndi ndalama zomwe zidagwiritsidwa ntchito".
Sikuti magalasi okhudzana ndi akatswiri amapereka masomphenya omveka bwino monga ma lens ena aliwonse, akutero Kollbaum, koma amawonjezera ubwino kwa odwala ndi ophthalmologists omwe akhala akuyang'ana njira yotsika mtengo komanso yabwino kwambiri yowonera maso awo kwa zaka zambiri.
"Maso ndi mbali yovuta kwambiri ya thupi, yofewa, yowonongeka komanso yozungulira kuposa khungu," akutero Lee."Tikukhulupirira kuti njira yathu ingasinthidwenso kuti ithandizire ndikuzindikira matenda ena osachiritsika amaso ndi ntchito zina."Akugwiranso ntchito ndi Boomerang Ventures, mgwirizano wa yunivesite ya Purdue, kuti abweretse luso lachipatala.
Kuwonjezera pa Lee ndi Kollbaum, gulu lofufuza likuphatikizapo Shin Ae Park, Seoul Ah Lee, Brian W. Buduris, Yumin Dai, Keely E. Harris, Bongjoon Kim, Ho Joon Kim, Kyunghoon Kim, Hyowon (Hyu) Lee, Kanggying Liu , Haesu Moon, Woohyun Park, Jay W. Shah ndi Jinyuan Zhang aku Indiana University, Don Meyer wa Indiana University School of Optometry, ndi Pedro Irazoki ndi Brett Kollar a Johns Hopkins University.
The technology was disclosed to the Purdue Research Foundation’s Office of Technology Commercialization (OTC), which filed a provisional patent with the USPTO to protect the intellectual property. For information on licensing options, please contact OTC’s Patrick Finnerty at pwfinnerty@prf.org at 2021-LEE-69240.
Ntchito ya Lee ku Weldon School of Biomedical Engineering ndi imodzi mwama projekiti osintha moyo opangidwa ndi aphunzitsi a uinjiniya wa biomedical ndi ophunzira.Ambiri mwa mapulogalamuwa ndi mgwirizano pakati pa Weldon, opereka chithandizo chamankhwala, ofufuza zamankhwala ndi makampani opanga zida zamankhwala omwe ali ofunikira kuti abweretse mbali zamaphunziro ndi ma labu ofufuza m'malo azachipatala.
Yunivesite ya Purdue ndi bungwe lotsogola lochita kafukufuku wa anthu lomwe ladzipereka kuti lipange mayankho ogwira mtima pamavuto ovuta masiku ano. Wosankhidwa m'zaka zisanu zapitazi ngati imodzi mwa mayunivesite 10 Otsogola Kwambiri ku United States ndi US News & World Report, Purdue imapereka kafukufuku wosintha padziko lonse lapansi komanso zomwe zapezeka padziko lapansi. Wosankhidwa m'zaka zisanu zapitazi ngati imodzi mwa mayunivesite 10 Otsogola Kwambiri ku United States ndi US News & World Report, Purdue imapereka kafukufuku wosintha padziko lonse lapansi komanso zomwe zapezeka padziko lapansi. Каждый из последних пяти лет Purdue входит в число 10 самых инновационных университетов США поверсии US News & World Report ndi проводидит иследованые, и проводит иследованый проводит иследование, и проводиты в проводит иследованые. Zaka zisanu zapitazi, Purdue adayikidwa m'gulu la mayunivesite 10 otsogola kwambiri ku US ndi US News & World Report ndipo akhala akuchita kafukufuku wosintha padziko lonse lapansi komanso zopeka zodabwitsa. Каждый из последних пяти лет Purdue был назван одним из 10 самых инновационных университетов в Соединенных Штатах по версиды, и песни US News & World. Zaka zisanu zapitazi, Purdue yatchulidwa kuti ndi imodzi mwa mayunivesite 10 otsogola kwambiri ku United States ndi US News & World Report, yopereka kafukufuku wosintha padziko lonse lapansi ndi zinthu zina zapadziko lapansi.Purdue adadzipereka pakuphunzira pamanja komanso pa intaneti mdziko lenileni, ndikupereka maphunziro osintha kwa aliyense.Yunivesite ya Purdue yadzipereka kuti ikhale yotsika mtengo komanso yotsika mtengo pochita maphunziro oziziritsa komanso chindapusa chambiri mchaka cha 2012-13, kulola ophunzira ambiri kuposa kale kuti amalize maphunziro awo opanda ngongole.Pitani ku https://stories.purdue.edu kuti muwone momwe Purdue samapumira pakudumpha kwake kotsatira.
Note to journalists: Images and videos of smart soft contact lenses are available on Google Drive. For a copy of the article, contact Matthew Oates at oatesw@purdue.edu.
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Nthawi yotumiza: Oct-10-2022
